重点实验室学术报告会通知(2026.4.7)
文章来源:生物质高值化利用研究中心生物质催化转化科研团 | 发布时间:2026-04-03 | 【打印】 【关闭】
应广东省可再生能源重点实验室的邀请,巴黎萨克雷大学分子化学与材料研究所(ICMMO)穆罕默德·梅拉(Mohamed MELLAH)教授将于2026年4月7日(周二)举行学术报告会。报告会安排如下:
时 间:2026年4月7日14:00-16:00
地 点:生物质能源大楼911会议室
报告题目:Use of electrochemistry to create efficient SmI2-mediated catalytic systems, the famous "Kagan reagent"
报告摘要:The development of sustainable and selective samarium-based catalytic systems remains a long-standing challenge in organic synthesis. Over the past decade, we have developed a Sm(II)-electrocatalytic strategy that enables the precise and tunable reduction of various functional groups, including carbonyls, imines, and nitro groups. This strategy also addresses the reduction of CO2, utilizing it as a C1 building block in organic chemistry to access valuable organic compounds. All these transformations were performed under mild and operationally simple electrochemical conditions. By controlling the electrolytic environment, complete selectivity toward the desired compounds is achieved. The method displays a broad substrate scope, excellent chemoselectivity, and high functional-group tolerance. Its synthetic potential is exemplified by the gram-scale synthesis of various drugs, such as naproxen and indobufen, a clinically relevant antiplatelet drug. Mechanistic investigations, including the isolation of key intermediates, deuterium-labeling studies, and electrochemical measurements, support a stepwise reductive pathway. This work establishes a versatile, green, and scalable Sm(II)-electrocatalytic platform for the controlled reduction of numerous compounds.
报告人简介:穆罕默德·梅拉(Mohamed MELLAH)博士为法国巴黎-萨克雷大学分子化学与材料研究所(ICMMO)教授,长期从事金属有机催化、不对称催化、有机电化学合成反应的研究和开发,成果丰硕。近20年来不断致力于开发稀土金属催化剂参与的电化学有机合成反应,在此领域已发表SCI论文40余篇,他所在的实验室在1970年代创造了二碘化钐(Kagan试剂),现已作为重要的单电子还原剂及路易斯酸被广泛应用于各类有机反应中。主持法国科研署重点研发计划三项以及多项法国卓越实验室计划项目。十多年来指导了10余名中国留学基金委(CSC)派出的学生攻读博士学位,对华友谊深厚。开发出“牺牲钐阳极法”制备SmI2的电化学新工艺,并将该模式成功应用于多种有机转化反应。尤其是近年来成功构建了新型电化学调控SmI2催化体系,该体系完全不含其他金属添加剂,已被应用于碳碳偶联反应(如频哪醇偶联和Barbier-Grignard交叉偶联反应)以及多类官能团的选择性催化还原反应。
参加人员:请生物质催化转化科研团队的老师和研究生参加,同时欢迎其他感兴趣的人员参加。

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